Lindsey Lepley

Assistant Professor


Assistant Professor, Department of Kinesiology

Academic Degrees:

Postdoctoral Fellow, University of Kentucky, Lexington, KY

Ph.D., University of Michigan, Ann Arbor, MI

M.Ed., University of Virginia, Charlottesville, VA

B.S., Grand Valley State University, Allendale, MI

Areas of Expertise:

Anterior Cruciate Ligament Injury and Reconstruction, Biomechanics, Muscle Inhibition, Muscle Mechanics


Dr. Lepley’s research interests center around examining the negative neuromuscular effects of traumatic joint injury and identifying therapeutic approaches capable of combating neuromuscular dysfunction. Much of her previous and current research has evaluated the effects of eccentric exercise on the recovery of muscle function after anterior cruciate ligament (ACL) reconstruction. Additionally, she studied the impact of muscle inhibition on persistent muscle weakness, and the consequences of muscle weakness on knee joint biomechanics. Her current projects look to study the effects of ACL injury on neuromuscular function in a rodent model, and the ability of exercise to promote muscle and joint health for the purpose of translating this work back into the clinic to minimize the risk of traumatic osteoarthritis development.

Funded Research:

  • Influence of eccentric exercise on muscle and joint health following ACL injury, Source: NIH, National Institute of Arthritis, Musculoskeletal and Skin Disease Research (1K01AR071503-01A1)
  • Eccentric exercise to promote immediate beneficial adaptations to muscle, Source: National Athletic Trainers’ Association Research and Education Foundation
  • Eccentric Cross-Exercise: A Novel Approach to Promote Recovery of Muscle Strength and Lower Extremity Function after ACL Reconstruction, Source: New England American College of Sports Medicine


  • Sport Optimization And Rehabilitation (SOAR) Division of the Human Performance Laboratory, Primary Faculty,
  • Comparative Orthopaedic Rehabilitation Laboratory, Director

Selected Publications:

Lepley LK, Lepley AS, Onate JA, Grooms DR. Eccentric Exercise to Enhance Neuromuscular Control. Sports Health: A Multidisciplinary Approach. 2017;9(4)333-340. PMID: 28571492

Lepley LK and Butterfield TA. Shifting the Current Clinical Perspective: Isolated Eccentric Exercise as an Effective Intervention to Promote the Recovery of Muscle After Injury. Journal of Sports Rehabilitation. 2017;26(5)122-130. PMID:28414268

Butterfield TA and Lepley LK. Eccentric Contractions: They Are Not So ‘Odd’ Anymore. Journal of Sport Rehabilitation.2017;26(5)117-119. PMID:28414266

Lepley LK, McKeon PO, Fitzpatrick SG, Beckemyer CL, Uhl TL, Butterfield TA. Neuromuscular Alterations After Ankle Sprains: An Animal Model to Establish Causal Links After Injury. Journal of Athletic Training. 2016;51(10):797-805. PMID:27831747

Lepley LK and Palmieri-Smith RM. Pre-operative Quadriceps Activation is related to Post-operative Activation, Not Strength, In Patients Post-ACL Reconstruction. Knee Surgery, Sports Traumatology, Arthroscopy. 2016;24(1):236-246. PMID:25315083

Lepley LK and Palmieri-Smith RM. Quadriceps Strength, Muscle Activation Failure and Patient-Reported Function at the Time of Return-to-Activity in ACL Reconstructed Patients: A Cross-sectional Study. Journal of Orthopedic & Sport Physical Therapy. 2015;45(12):1017-1025. PMID:26471854

Thomas AC, Lepley LK, Wojtys EM, McLean SG, Palmieri-Smith RM. Effects of Neuromuscular Fatigue and Quadriceps Inhibition and Knee Biomechanics in Individuals post ACL Reconstruction and Healthy Adults. Journal of Orthopedic & Sports Physical Therapy. 2015;45(12):1042-1050. PMID:26471851

Lepley LK, Wojtys EM, Palmieri-Smith RM. Combination of Eccentric Exercise and Neuromuscular Electrical Stimulation Post-ACL Reconstruction to Improve Biomechanical Limb Symmetry After Anterior Cruciate Ligament Reconstruction. Clinical Biomechanics. 2015;30(7):738-747. PMID:25953255

Lepley LK, Wojtys EM, Palmieri-Smith RM. Does Concomitant Meniscectomy or Meniscal Repair Affect the Recovery of Quadriceps Function Post-ACL Reconstruction? Knee Surgery, Sport Traumatology, Arthroscopy. 2015;23(9):2756-2761. PMID:24906435

Palmieri-Smith RM and Lepley LK. Quadriceps Strength Asymmetry Following ACL Reconstruction Alters Knee Joint Biomechanics and Functional Performance at Time of Return to Activity. The American Journal of Sports Medicine. 2015;43(7):1662-1669. PMID:25883169

Lepley LK. Deficits in Quadriceps Strength and Patient Oriented Outcomes at Return-to-Activity Following ACL Reconstruction: A Review of the Current Literature. Sports Health: A Multidisciplinary Approach. 2015;7(3):231-238. PMID:26131300

Lepley LK, Wojtys EM, Palmieri-Smith RM. Combination of Eccentric Exercise and Neuromuscular Electrical Stimulation Post-ACL Reconstruction to Improve Quadriceps Function. The Knee. 2015;22(3):270-277. PMID:25819154. NATAREF 2016 Doctoral Dissertation Award

Lepley LK and Palmieri-Smith RM. Cross-Education Strength and Activation After Eccentric Exercise. Journal of Athletic Training. 2014;49(5):582-589. PMID:25117873

Lepley LK and Palmieri-Smith RM. Effect of Eccentric Strengthening After Anterior Cruciate Ligament Reconstruction on Quadriceps Strength. Journal of Sports Rehabilitation. 2013;22(2):150-156. PMID:23238230

Lepley LK, Thomas AC, McLean SG, Palmieri-Smith RM. Fatigue’s Lack of Effect on Thigh-Muscle Activity in Anterior Cruciate Ligament-Reconstructed Patients During a Dynamic-Landing Task. Journal of Sports Rehabilitation. 2013;22(2):83-92. PMID:23069653

Honors and Awards:

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases, Loan Repayment Award, 2016-2018
  • NATA Research & Education Foundation Doctoral Dissertation Award, 2016
  • New England American College of Sports Medicine New Investigator Award, 2015
  • Univ. of Kentucky Center for Muscle Biology Postdoctoral Fellow Award, 2014
  • Univ. of Michigan Paul A. Hunsicker Memorial Award, 2014
  • Univ. of Virginia David H. Perrin Athletic Training & Sports Medicine Award, 2009


  • American College of Sports Medicine
  • American Society of Biomechanics
  • Athletic Trainers’ Osteoarthritis Consortium
  • National Athletic Trainers’ Association
Contact Information
Mailing Address2095 Hillside Rd, Unit 1110 Storrs, CT 06269-1110
Office LocationGampel Pavilion